Inducible Mouse Models for Cancer Drug Target Validation

Inducible Mouse Models for Cancer Drug Target Validation

Genetically-engineered mouse (GEM) models have provided significant contributions to our understanding of cancer biology and developing anticancer therapeutic strategies. The development of GEM models that faithfully recapitulate histopathological and clinical features of human cancers is one of the most pressing needs to successfully conquer cancer. In particular, doxycycline-inducible transge...

Advanced Models for Target Validation & Drug Discovery in Prostate Cancer

Drug target validation: lethal infection blocked by inducible peptide.

Genome projects are generating large numbers of potential new targets for drug discovery. One challenge is target validation, proving the usefulness of a specific target in an animal model. In this paper, we demonstrate a new approach to validation and assay development. We selected in vitro specific peptide binders to a potential pathogen target. By inducing the expression of a selected peptid...

Target validation: A door to drug discovery.

From ancient times to today, drug discovery transitioned from serendipity to rationality over its long history. Proper drug target selection and validation are crucial to the discovery of new drugs. This review discusses the definition of drug targets and proposes several characteristics for drug targets. The limitations of the term 'target' itself are summarized. The drug target validation pro...

Genetically Engineered Mouse Models in Preclinical Anti-Cancer Drug Development

According to the most recent American Cancer Society data, an estimated 569,490 Americans died from cancer in 2010 (American Cancer Society [ACS], 2010). The number of cancer-related deaths recently surpassed those from heart disease in Americans <85 yrs old (Kung et al., 2008). Developing new and more efficacious anti-cancer compounds is a paramount health care priority. At the Developmental T...